Dosage ; Adult and children over 16yrs; 100-1000mg BD:
Children over 6 years; 50-100mg BD.
Combinations ; - see below
1.Fluticasone propionate inhaler
2. Fluticasone propionate nasal spray Brands
3. Fluticasone Propionate (skin) Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Flixotide | GlaxoSmithkline | GlaxoSmithKline | 50mcg | 120 doses | inhaler | per actuation | KES 581.70 |
| Flixotide | GlaxoSmithkline | GlaxoSmithKline | 0.125mg | 120 doses | inhaler | per actuation | KES 1,169.30 |
| Flixotide | GlaxoSmithkline | GlaxoSmithKline | 0.25mg | 120 doses | inhaler | per actuation | KES 1,351.50 |
| Fluticasone propionate inhaler More info | |
|---|---|
| Mode Of Action | Corticosteroids activity involve inhibition of various process that are involved in the inflammation e.g. inhibition of secretion of growth factors, endothelial activating and other cytokines from lymphocytes, eosinophils, macrophages, fibroblasts, and mast cells. The net effect is to reduce the chronic inflammation in asthmatic airways. |
| Drug Indication | Prevention of bronchial asthma (not for acute attack) not well controlled by the bronchodilators |
| Precautions | Active pulmonary TB; airways obstruction; times of stress; gradual withdrawal of systematic steroid therapy; respiratory infections. |
| Contra-Indications | Status asthmaticus; safety in pregnancy and lactation not yet fully established; acute asthma attack; untreated airways infections; recurrent nasal bleeding. |
| Side Effects | Throat candidiasis; hoarseness of the voice; throat irritation; paradoxical bronchospasm (discontinue); adrenal suppression; cataract formation after prolonged use; cutaneous hypersensitivity reactions; cough and sneeze due to irritation; pulmonary infiltrates. |
| Dosage | Adult and children over 16yrs; 100-1000mg BD: Children over 6 years; 50-100mg BD. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTING ON RESPIRATORY SYSTEM |
| Drug Sub-Category | Inhalers |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Ltd. | Ltd | mg | 30 | Tablet | per tablet | KES | |
| Ltd | (K) Ltd. | mg | 30 | Tablet | per tablet | KES |
| Fluticasone propionate nasal spray More info | |
|---|---|
| Drug Indication | Prophylaxis and treatment of seasonal and perennial allergic rhinitis and hay fever |
| Precautions | Treatment of the infections of the nose and pharynx before using this medicine; gradual withdrawal of exogenous steroids; transfer of patients from systemic steroid treatment; nasal trauma; recent nasal surgery. |
| Contra-Indications | History of recurrent nasal bleeding; untreated bacterial/viral/fungal infections; children under 6yrs; unhealed nasal wound; pregnancy. |
| Side Effects | Epistaxis; nasal septum perforation; unpleasant taste and smell; glaucoma; increase IOP; haemorrhagic nasal discharge; stuffy nose; local candidal infections |
| Dosage | Children 4-11yrs: inhale into each nostril once daily, increased to twice daily (max. 4 sprays daily). Adults and children over 12yrs: inhale two sprays once daily to a max. of 8 sprays daily. |
| Drug Category | DRUGS ACTING ON ENT |
| Drug Sub-Category | Steroid hormones and related synthetic drugs |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Cutivate | GlaxoSmithkline | GlaxoSmithKline | 0.05% | 15gm | Cream | KES 564.10 | |
| Cutivate | GlaxoSmithkline | GlaxoSmithKline | 0.05% | 30gm | Cream | KES 655.40 | |
| Cutivate | GlaxoSmithkline | GlaxoSmithKline | 0.05% | 15gm | Ointment | KES 564.10 | |
| Cutivate | GlaxoSmithkline | GlaxoSmithKline | 0.05% | 30gm | Ointment | KES 655.40 | |
| Ticas | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 0.05% | 10gm | Cream | KES 250.00 |
| Fluticasone Propionate (skin) More info | |
|---|---|
| Mode Of Action | It diffuses across cell membranes and forms a complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, binds to DNA, and stimulate transcription of messenger RNA (mRNA). Messenger RNA leads to protein synthesis of various enzymes that are responsible for the effects of systemic corticosteroids |
| Drug Indication | Relief of some inflammatory conditions when potentially less harmful measures are ineffective |
| Precautions | Limit use in children or on face to maximum of 5 days. It should be withdrawn gradually following prolonged therapy. Unless fully unavoidable, potent corticosteroids should not be used on the face as they may precipitate a rosacea-like disorder and aggravate any pre-existing rosacea, avoid use in an occluded area, near the eye, use in the presence of skin infections without concomitant use of anti-microbial, children under 1yr, on weeping foci. |
| Contra-Indications | Use on rosacea acne, peri-oral dermatitis, scabies, leg ulcers, tuberculous, untreated viral, bacterial or fungal infections, reaction to smallpox vaccination, first three months of pregnancy, continous prophylactic use. |
| Side Effects | Local irritation e.g burning sensation and itching, erythema rare, dryness of the skin, aggravation of concurrent untreated infections, thinning of the skin (this may be reversible), loss of skin elasticity, folliculitis, change in skin pigmentation, telangiectasia, purpura and steroid acne, increased growth of hair, severe pituitary-adrenal axis suppression and hypercotism, cushoid state, growth retardation, benign intra-cranial hypertension. |
| Dosage | Applied once daily |
| Drug Category | DERMATOLOGICAL PREPARATIONS |
| Drug Sub-Category | Topical Corticosteroids |